IngredientStudied forEvidence in shortUsual form
Biotin Hair, skin and nail quality Strongest in deficiency states; limited for people who are not deficient Tablet, capsule, powder, multi-nutrient blend
Calcium Bones and teeth Bone outcomes studied mainly with vitamin D; the amount per serving and dose splitting matter Tablet, capsule, chewable, powder; carbonate or citrate forms
Chromium Nutrient metabolism Weak and inconsistent overall; rare harm reported at high doses; no Japanese nutrient claim Tablet, capsule; chromium picolinate or other chelated forms
Copper Red blood cell formation; enzyme function and bone formation Established nutrient function; supplementation research is mostly about avoiding an imbalance with zinc Tablet, capsule; combined with zinc in mineral formulas
Folic Acid Red blood cell formation; fetal development in early pregnancy Strong trial evidence around early pregnancy; high intake can mask a B12 shortfall Tablet, capsule; folic acid or food folate
Iodine Thyroid hormone production Essential but narrow safe range; Japanese diets already high; kelp content varies widely Tablet, capsule; potassium iodide or seaweed-derived
Iron Red blood cell formation; everyday fatigue Modest fatigue benefit in iron-deficient adults; excess intake is the key safety issue Tablet, capsule; sulfate, gluconate, fumarate or bisglycinate forms
Magnesium Bones, energy production; sleep quality Sleep evidence inconsistent and low-certainty; one recent RCT found a modest benefit Tablet, capsule, powder; citrate, oxide, bisglycinate or other salt forms
Multivitamin Filling everyday nutrient gaps; cognition in older adults Large trials show modest or no effects in well-nourished adults; upper limits drive the design Tablet, capsule, powder stick
Potassium Normal muscle and nerve function; sodium balance Studied mainly in patient groups; Japan’s nutrient claim excludes tablets and capsules Powder, drink mix; NOT eligible for Japan's nutrient-function claim in tablet or capsule form
Selenium Antioxidant-related nutrient status Not a Japanese Nutrient Function Claims mineral; large prevention trial found no benefit Tablet, capsule; selenomethionine or sodium selenite
Vitamin A / Beta-carotene Night vision, skin and mucous membrane maintenance Established nutrient function; high-dose beta-carotene in smokers showed harm, not benefit Tablet, capsule, softgel; retinyl palmitate or beta-carotene
Vitamin B complex Energy metabolism; everyday fatigue Benefits mixed to null in people who are not deficient; fixed Japanese nutrient wording available Tablet, capsule, drink
Vitamin C Immune function; skin and collagen No prevention effect in the general population; modest effects under heavy physical exertion Tablet, chewable, capsule, powder
Vitamin D Calcium absorption and bones; immune function Large VITAL trial found no broad benefit in people with enough vitamin D; helps most where levels are low Softgel, tablet, oral drops
Vitamin E Antioxidant function Large long-term trials found no broad benefit and a safety signal at high doses Soft capsule, tablet, oil
Vitamin K2 (MK-4 / MK-7) Bone-related markers in midlife and older women Few trials, bone-related markers at very different doses; MK-4 and MK-7 are not interchangeable Capsule, tablet, softgel
Zinc Taste, skin and immune function May shorten cold duration (low-certainty evidence); little or no preventive effect; side effects more common Tablet, capsule, lozenge; gluconate, citrate, oxide or sulfate forms